Pharmacological Inhibition of p38 Mitogen-Activated Protein Kinases Affects KC/CXCL1-Induced Intraluminal Crawling, Transendothelial Migration, and Chemotaxis of Neutrophils In Vivo
Figure 6
Effect of SB203580 on KC-induced neutrophil migration and chemotaxis. (a) The velocity of neutrophil migration in response to KC stimulation in the absence (control, white) and in the presence (black) of p38 MAPK inhibitor SB203580 (100 nM) 30 min following the placement of KC-containing gel. Data are means ± SEM (). * indicates significant difference () from the control without SB203580 (t-test). (b) The chemotaxis index (CI) in response to KC stimulation in the absence (control, white) and in the presence (black) of p38 MAPK inhibitor SB203580 (100 nM) 30 min following the placement of KC-containing gel. Data are means ± SEM (). ** indicates significant difference () from the control without SB203580 (t-test).
