4-Methoxycarbonyl Curcumin: A Unique Inhibitor of Both Inflammatory Mediators and Periodontal Inflammation
Figure 1
Inhibition of TNF-α levels by curcumin and CMC 2.5 in PBMC cells. PBMC cells (5 × 105 cells/well) were cultured in serum-free media (37°C, 95% air, 5% CO2) for 18 hours with LPS (P. gingivalis, 50 ng/mL) or vehicle alone. Curcumin or CMC 2.5 was added at final concentrations of 2 or 5 μM. Conditioned medium was analysed for TNF-α by ELISA. Each value represents the mean of 3 cultures ± the standard error of the mean (S.E.M.). * represents the significance of all groups of curcumin and CMC 2.5 compared to LPS alone; ** represents the significance between LPS + 5 μM curcumin and LPS + 5 μM CMC 2.5.
