4-Methoxycarbonyl Curcumin: A Unique Inhibitor of Both Inflammatory Mediators and Periodontal Inflammation
Figure 8
The effect of diabetes and orally administered CMC 2.5 on gingival MMPs (-2, -9) and IL-1β. Gingival tissue from diabetic rats treated with vehicle or CMC 2.5 was obtained and pooled by group as described in Section 2, since insufficient gingival tissue is usually available for individual analysis. Gingival tissues were then extracted and aliquots of each gingival extract were measured for MMP-2 and MMP-9 by gelatin zymography and were scanned densitometrically to quantify gelatinase activity, and IL-1β was measured by ELISA. NDC: nondiabetic control; UD: untreated diabetic.
