Haplotype Analysis of Interleukin-8 Gene Polymorphisms in Chronic and Aggressive Periodontitis
Table 2
Genotype and allele frequencies of IL8 polymorphisms in control and periodontitis subgroups.
SNP
Genotype
Controls (%)
CP (%)
value*
OR (95% CI)
AgP (%)
value*
OR (95% CI)
IL8 −251T/A (rs4073)
TT
49 (31.4)
95 (34.2)
—
1.00
18 (31.0)
—
1.00
TA
78 (50.0)
120 (43.2)
0.37
0.76 (0.47–1.23)
27 (46.6)
0.76
1.08 (0.49–2.37)
AA
29 (18.6)
63 (22.7)
0.78
1.22 (0.67–2.21)
13 (22.4)
0.67
1.27 (0.47–3.38)
Allele
T
176 (56.4)
310 (55.8)
0.60
1.00
62 (53.4)
0.33
1.00
A
136 (43.6)
246 (44.2)
0.93 (0.69–1.25)
54 (46.6)
0.89 (0.55–1.44)
IL8 +396T/G (rs2227307)
TT
54 (34.6)
100 (36.0)
—
1.00
20 (34.5)
—
1.00
TG
74 (47.4)
118 (42.4)
0.58
0.86 (0.54–1.39)
27 (46.6)
0.74
1.15 (0.54–2.45)
GG
28 (17.9)
60 (21.6)
0.67
1.28 (0.71–2.31)
11 (19.0)
0.92
1.00 (0.36–2.82)
Allele
T
182 (58.3)
318 (57.2)
0.83
1.00
67 (57.8)
0.89
1.00
G
130 (41.7)
238 (42.8)
0.91 (0.68–1.23)
49 (42.2)
0.99 (0.61–1.62)
IL8 +781C/T (rs2227306)
CC
55 (35.3)
103 (37.1)
—
1.00
20 (34.5)
—
1.00
CT
76 (48.7)
121 (43.5)
0.51
0.82 (0.52–1.31)
27 (46.6)
0.84
1.10 (0.52–2.34)
TT
25 (16.0)
54 (19.4)
0.66
1.24 (0.67–2.31)
11 (19.0)
0.66
1.07 (0.38–3.02)
Allele
T
186 (59.6)
327 (58.8)
0.44
1.00
67 (57.8)
0.68
1.00
C
126 (40.4)
229 (41.2)
1.06 (0.78–1.43)
49 (42.2)
1.05 (0.64–1.70)
IL8 −845T/C (rs2227532)
TT
52 (100.0)
120 (98.4)
—
1.00
19 (100.0)
—
1.00
TC
0 (0.0)
2 (1.6)
0.49
#
0 (0.0)
1.00
#
CC
0 (0.0)
0 (0.0)
1.00
#
0 (0.0)
1.00
#
Allele
T
104 (100.0)
242 (99.2)
0.49
1.00
38 (100.0)
1.00
1.00
C
0 (0.0)
2 (0.8)
#
0 (0.0)
#
Differences between individual haplotypes (between controls and CP or controls and AgP) were analyzed using the Fisher exact test. OR: odds ratio adjusted for age, sex, and smoking in logistic regression, reference categories designated with an OR of 1.0; CI: confidence interval, #nonapplicable (small numbers); #OR not calculated because of the presence of zero values.
