Haplotype Analysis of Interleukin-8 Gene Polymorphisms in Chronic and Aggressive Periodontitis
Table 3
Distribution of IL8 haplotypes in the studied groups.
Haplotypes (alleles of IL8 SNPs)
Controls (%)
CP (%)
OR (95% CI)
AgP (%)
OR (95% CI)
IL8 −251T/A (rs4073)
IL8+396T/G (rs2227307)
IL8 +781C/T (rs2227306)
T
T
C
162 (51.9)
293 (52.7)
NS
0.99 (0.73–1.32)
62 (53.4)
NS
1.02 (0.63–1.65)
A
G
T
110 (35.3)
212 (38.1)
NS
1.17 (0.86–1.59)
46 (39.7)
NS
1.14 (0.70–1.87)
A
T
T
16 (5.1)
11 (2.0)
0.018
0.34 (0.15–0.78)
3 (2.6)
NS
0.62 (0.18–2.20)
T
G
C
14 (4.5)
11 (2.0)
0.048
0.41 (0.18–0.97)
2 (1.7)
NS
0.51 (0.11–2.30)
A
G
C
6 (1.9)
12 (2.2)
NS
1.40 (0.47–4.12)
2 (1.7)
NS
1.22 (0.23–6.35)
A
T
C
4 (1.3)
11 (2.0)
NS
1.79 (0.54–5.90)
1 (0.9)
NS
1.01 (0.11–9.29)
T
T
T
0 (0.0)
3 (0.5)
NS
*
0 (0.0)
NS
*
T
G
T
0 (0.0)
3 (0.5)
NS
*
0 (0.0)
NS
*
= NS
= NS
OR: odds ratio adjusted for age, sex, and smoking in logistic regression CI: confidence intervals.
aDifferences between individual haplotypes (between controls and CP or controls and AgP) were analyzed using the Fisher exact test.
*OR not calculated because of the presence of zero values. Bold: significant result.
