Protective Effects of Polydatin on Septic Lung Injury in Mice via Upregulation of HO-1

Figure 5

Effects of PD on the protein expression of COX-2 and iNOS (a), and PGE₂ (b), and NO (c) production in the lungs of mice. Mice were pretreated i.p. with vehicle (PBS) or PD (15, 45, and 100 mg/kg, resp.) in the presence or absence of ZnPP IX (40 mg/kg) 1 h before CLP. The lung tissues were obtained 24 h after CLP for evaluation of COX-2, iNOS, PGE₂, and NO. Results are expressed as mean ± SD (𝑛=6). ^∗𝑃<0.05, ^∗∗𝑃<0.01 versus the CLP group. ^##𝑃<0.01 versus the CLP-PD group.

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