STAT3 Regulates Proliferation and Survival of CD8+ T Cells: Enhances Effector Responses to HSV-1 Infection, and Inhibits IL-10+ Regulatory CD8+ T Cells in Autoimmune Uveitis
Figure 4
STAT3KO mice are defective in generating HSV-1 specific CD8+ effector T cells in response to HSV-1 infection. (a–d) C57BL/6 mice were infected with HSV-1, and immune response to the virus was assessed by FACS analysis. (a) Virus-specific response was established and assessed in the WT mouse by FACS using gB-tetramers. (b–d), Analysis of CD4+ and CD8+ T cell responses to HSV-1 (b), activated virus-specific CD8+ T cells (c), and IFN-γ production by the HSV-1-specific CD4/CD8 T cells (d). Cells were gated on CD8 (a, c) or CD3 (b, d), and numbers in quadrants represent percentage of tetramer positive CD8+ T cells or T cells expressing KLRG, CD62L, CD4, CD8, or IFN-γ. Data represent at least 3 independent experiments.
