MMP-3 Contributes to Nigrostriatal Dopaminergic Neuronal Loss, BBB Damage, and Neuroinflammation in an MPTP Mouse Model of Parkinson’s Disease

Figure 5

MPTP-induced increases in ED-1 and CD-3-ip cells are suppressed in the SNpc of MMP-3^−/− mouse brain. ((a–f)) Sections adjacent to those used for FITC-linked albumin staining were examined for ED-1 or CD-3 immunostaining. (g) Bars represent the numbers of ED-1 or CD-3-ip cells in the SNpc, respectively. Four or five animals were used for each experimental group. Dotted lines indicate the SNpc. Scale bar, 100 μm. Two-way ANOVA with Bonferroni post hoc test, ED-1-ip cells; (𝐹(1,15)=45.67, 𝑃<0.001), CD-3-ip cells; (𝐹(1,15)=13.72, 𝑃<0.01), ^∗∗∗𝑃<0.001, significantly different from PBS-injected MMP-3^+/+ mice;   ^#𝑃<0.05, significantly different from MPTP-injected MMP-3^+/+ mice.

(a)

(b)

(c)

(d)

(e)

(f)

(g)