Parthenolide Is Neuroprotective in Rat Experimental Stroke Model: Downregulating NF-B, Phospho-p38MAPK, and Caspase-1 and Ameliorating BBB Permeability
Figure 2
PN improved neurological outcome after MCAO. (a) shows the neurological deficit scores at 24 h. Each circle represented the score for a single rat. Compared with MCAO group, the neurological deficit scores were significantly decreased in High group at 24 h and 72 h. versus MCAO group. (b) shows the water content of ipsilateral hemispheres. Compared with MCAO group, the brain water content of ipsilateral hemispheres significantly was reduced in High group at 24 h and 72 h, but only at 72 h in Low group after MCAO versus MCAO group. (d) shows infarct volume at 24 h and 72 h. Compared with MCAO group, the infarct area was significantly reduced in High group at 24 h and 72 h, but only at 72 h in Low group after MCAO. versus MCAO group. Representative photographs in (c) shows brain slices stained with TTC.
