Parthenolide Is Neuroprotective in Rat Experimental Stroke Model: Downregulating NF-B, Phospho-p38MAPK, and Caspase-1 and Ameliorating BBB Permeability
Figure 4
PN decreased protein of active caspase-1, phospho-p38MAPK, and nuclear NF-κB p65 after MCAO. (b) shows the expression of active caspase-1. Compared with MCAO group, the expression of active caspase-1 was significantly decreased in High group at 24 h and 72 h. (d) shows the expression of phospho-p38MAPK. (f) shows the expression of nuclear protein NF-κB. Compared with MCAO group, the expression of phospho-p38MAPK and nuclear protein NF-κB was significantly decreased in High group both at 24 h and 72 h, but decreased only at 72 h in Low group versus MCAO group. Representative photographs in ((a), (c), (e)) show the influence of PN on protein of active caspase-1, phospho-p38MAPK, and nuclear protein NF-κB at 72 h.
