The Mechanism of Sevoflurane Preconditioning-Induced Protections against Small Intestinal Ischemia Reperfusion Injury Is Independent of Mast Cell in Rats

Figure 2

Morphological changes of intestine and intestinal histological score under light microscope after IIR injury. (a) is representative image of SH group (Sham-operated group), IIR group (75 min intestinal ischemia and 2 h reperfusion), IIR + CP group (IIR group + Compound 48/80 1 mg/kg), IIR + CS group (50 mg/kg cromolyn sodium treated IIR group), IIR + CS + CP group (50 mg/kg cromolyn sodium treated IIR group + Compound 48/80 1 mg/kg), SEV + IIR group (2.3% sevoflurane pretreated IIR group), and SEV + IIR + CP group (2.3% sevoflurane pretreated IIR group + Compound 48/80 1 mg/kg), (HE staining, ×100). Bar graph in (b) quantified the intestine histological scores. Results are expressed as Mean ± SEM. 𝑛=6 per group. ^∗𝑃<0.05 versus SH group, ^#𝑃<0.05 versus IIR group, ^$𝑃<0.05 versus IIR + CP group, ^&𝑃<0.05 versus IIR + CS group, and ^∧𝑃<0.05 versus SEV + IIR group.

(a)

(b)