Heat Shock Proteins 60 and 70 Specific Proinflammatory and Cytotoxic Response of CD4+CD28null Cells in Chronic Kidney Disease
Elispot counts of IFN-, perforin, and granzyme B in CD4+CD28null cells and CD4+CD28+ cells in CKD subjects. (a) Unstimulated cells: expression of IFN-, perforin, and granzyme B was significantly higher in CD4+CD28null T-cells. Elispot counts of (b) IFN-, (c) perforin and (d) granzyme B were significantly increased after 48 hr stimulation with HSP60 (5 ng/mL) and HSP70 (5 ng/mL) as compared to unstimulated control in CD4+CD28null cells as well as CD4+CD28+ cells. PHA (10 g/mL) served as positive control. **, *, #.
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