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Mediators of Inflammation
Volume 2013, Article ID 392746, 10 pages
http://dx.doi.org/10.1155/2013/392746
Clinical Study

Human Leukocyte Antigen Class II Alleles (DQB1 and DRB1) as Predictors for Response to Interferon Therapy in HCV Genotype 4

1Departments of Medical Biochemistry & Molecular Biology, Faculty of Medicine, Cairo University, Cairo, Egypt
2Department of Zoology, Faculty of Science, Cairo University, Cairo 12613, Egypt
3Departments of Tropical Medicine & Hepatology, Faculty of Medicine, Cairo University, Cairo, Egypt
4Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA

Received 8 November 2012; Revised 7 January 2013; Accepted 20 January 2013

Academic Editor: Antonio Macciò

Copyright © 2013 Olfat Shaker et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Deuffic-Burban, M. K. Mohamed, B. Larouze, F. Carrat, and A. J. Valleron, “Expected increase in hepatitis C-related mortality in Egypt due to pre-2000 infections,” Journal of Hepatology, vol. 44, no. 3, pp. 455–461, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Elkady, Y. Tanaka, F. Kurbanov et al., “Genetic variability of hepatitis C virus in south Egypt and its possible clinical implication,” Journal of Medical Virology, vol. 81, no. 6, pp. 1015–1023, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. V. K. Rustgi, “The epidemiology of hepatitis C infection in the United States,” Journal of Gastroenterology, vol. 42, no. 7, pp. 513–521, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. H. El Makhzangy, G. Esmat, M. Said et al., “Response to pegylated interferon alfa-2a and ribavirin in chronic hepatitis C genotype 4,” Journal of Medical Virology, vol. 81, no. 9, pp. 1576–1583, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. Z. Bhatti and C. S. Berenson, “Adult systemic cat scratch disease associated with therapy for hepatitis C,” BMC Infectious Diseases, vol. 7, article 8, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. H. E. Harris, K. P. Eldridge, S. Harbour et al., “Does the clinical outcome of hepatitis C infection vary with the infecting hepatitis C virus type?” Journal of Viral Hepatitis, vol. 14, no. 3, pp. 213–220, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. C. Y. Dai, W. L. Chuang, M. Y. Hsieh et al., “Human leukocyte antigen alleles and the response to pegylated interferon/ribavirin therapy in chronic hepatitis C patients,” Antiviral Research, vol. 85, no. 2, pp. 396–402, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Villadangos, “Presentation of antigens by MHC class II molecules: getting the most out of them,” Molecular Immunology, vol. 38, pp. 329–346, 2001. View at Publisher · View at Google Scholar
  9. J. A. Traherne, “Human MHC architecture and evolution: implications for disease association studies,” International Journal of Immunogenetics, vol. 35, no. 3, pp. 179–192, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. T. Shiina, K. Hosomichi, H. Inoko, and J. K. Kulski, “The HLA genomic loci map: expression, interaction, diversity and disease,” Journal of Human Genetics, vol. 54, no. 1, pp. 15–39, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. J. Timm, B. Li, M. G. Daniels et al., “Human leukocyte antigen-associated sequence polymorphisms in hepatitis C virus reveal reproducible immune responses and constraints on viral evolution,” Hepatology, vol. 46, no. 2, pp. 339–349, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. X. Hong, R. B. Yu, N. X. Sun, B. Wang, Y. C. Xu, and G. L. Wu, “Human leukocyte antigen class II DQB1*0301, DRB1*1101 alleles and spontaneous clearance of hepatitis C infection: a meta-analysis,” World Journal of Gastroenterology, vol. 11, no. 46, pp. 7302–7307, 2005. View at Google Scholar · View at Scopus
  13. M. G. Isagulyants and N. N. Ozeretskovskaya, “Role of a host in spontaneous recovery from viral hepatitis C: genetic predetermined factors,” Voprosy Virusologii, vol. 53, no. 6, pp. 40–45, 2008. View at Google Scholar · View at Scopus
  14. A. Yenigün and B. Durupinar, “Decreased frequency of the HLA-DRB1*11 allele in patients with chronic hepatitis C virus infection,” Journal of Virology, vol. 76, no. 4, pp. 1787–1789, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. R. A. Harris, K. Sugimoto, D. E. Kaplan, F. Ikeda, M. Kamoun, and K. M. Chang, “Human leukocyte antigen class II associations with hepatitis C virus clearance and virus-specific CD4 T cell response among Caucasians and African Americans,” Hepatology, vol. 48, no. 1, pp. 70–79, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. R. Singh, R. Kaul, A. Kaul, and K. Khan, “A comparative review of HLA associates with hepatitis B and C viral infections across global populations,” World Journal of Gastroenterology, vol. 13, no. 12, pp. 1770–1787, 2007. View at Google Scholar · View at Scopus
  17. L. Cangussu, R. Teixeira, E. Campos et al., “HLA class II alleles and chronic hepatitis C virus infection,” Journal of Clinical Immunology, vol. 74, no. 3, pp. 282–287, 2011. View at Google Scholar
  18. L. Ali, A. Mansoor, N. Ahmad et al., “Patient HLA-DRB1* and -DQB1* allele and haplotype association with hepatitis C virus persistence and clearance,” Journal of General Virology, vol. 91, no. 8, pp. 1931–1938, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Jiao and J. B. Wang, “Hepatitis C virus genotypes, HLA-DRB alleles and their response to interferon-α and ribavirin in patients with chronic hepatitis C,” Hepatobiliary and Pancreatic Diseases International, vol. 4, no. 1, pp. 80–83, 2005. View at Google Scholar · View at Scopus
  20. P. M. de Rueda, M. N. López-Nevot, P. Sáenz-López et al., “Importance of host genetic factors HLA and IL28B as predictors of response to pegylated interferon and ribavirin,” American Journal of Gastroenterology, vol. 106, no. 7, pp. 1246–1254, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. O. Hendy, E. Abd Elmonean, M. Allam et al., “Human leukocyte antigen class II, (HLA-II) alleles and interferon response in HCV chronically infected Egyptian patients,” International Research Journal of Microbiology, vol. 2, no. 4, pp. 133–140, 2011. View at Google Scholar
  22. P. Bedossa and T. Poynard, “An algorithm for the grading of activity in chronic hepatitis C,” Hepatology, vol. 24, no. 2, pp. 289–293, 1996. View at Publisher · View at Google Scholar · View at Scopus
  23. D. Roulot, V. Bourcier, V. Grando et al., “Epidemiological characteristics and response to peginterferon plus ribavirin treatment of hepatitis C virus genotype 4 infection,” Journal of Viral Hepatitis, vol. 14, no. 7, pp. 460–467, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. R. R. Gad, S. Males, H. El Makhzangy et al., “Predictors of a sustained virological response in patients with genotype 4 chronic hepatitis C,” Liver International, vol. 28, no. 8, pp. 1112–1119, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. R. Bruno, P. Sacchi, L. Maiocchi, C. Zocchetti, and G. Filice, “Host factors affecting the outcome of treatment of hepatitis C,” Reviews in Gastroenterological Disorders, vol. 4, supplement 1, pp. S3–S7, 2004. View at Google Scholar · View at Scopus
  26. C. Morishima, S. J. Polyak, R. Ray et al., “Hepatitis C virus-specific immune responses and quasi-species variability at baseline are associated with nonresponse to antiviral therapy during advanced hepatitis C,” Journal of Infectious Diseases, vol. 193, no. 7, pp. 931–940, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. S. J. Hadziyannis, H. Sette, T. R. Morgan et al., “Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis C: a randomized study of treatment duration and ribavirin dose,” Annals of Internal Medicine, vol. 140, no. 5, pp. 346–355, 2004. View at Google Scholar · View at Scopus
  28. N. Akuta, F. Suzuki, H. Sezaki et al., “Predictive factors of virological non-response to interferon-ribavirin combination therapy for patients infected with hepatitis C virus of genotype1b and high viral load,” Journal of Medical Virology, vol. 78, no. 1, pp. 83–90, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. Z. Lombard, A. E. Brune, E. G. Hoal et al., “HLA class II disease associations in Southern Africa,” Tissue Antigens, vol. 67, no. 2, pp. 97–110, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. V. de Re, L. Caggiari, G. Monti et al., “HLA DR-DQ combination associated with the increased risk of developing human HCV positive non-Hodgkin's lymphoma is related to the type II mixed cryoglobulinemia,” Tissue Antigens, vol. 75, no. 2, pp. 127–135, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. H. Sim, J. Wojcik, M. Margulies, J. A. Wade, and J. Heathcote, “Response to interferon therapy: influence of human leucocyte antigen alleles in patients with chronic hepatitis C,” Journal of Viral Hepatitis, vol. 5, no. 4, pp. 249–253, 1998. View at Publisher · View at Google Scholar · View at Scopus
  32. M. L. Yu, C. Y. Dai, S. C. Chen et al., “Human leukocyte antigen class I and II alleles and response to interferon-α treatment, in Taiwanese patients with chronic hepatitis C virus infection,” Journal of Infectious Diseases, vol. 188, no. 1, pp. 62–65, 2003. View at Publisher · View at Google Scholar · View at Scopus
  33. Y. Itoh, H. Inoko, J. K. Kulski et al., “Four-digit allele genotyping of the HLA-A and HLA-B genes in Japanese patients with Behcet's disease by a PCR-SSOP-Luminex method,” Tissue Antigens, vol. 67, no. 5, pp. 390–394, 2006. View at Publisher · View at Google Scholar · View at Scopus
  34. F. M. Heinemann, “HLA genotyping and antibody characterization using the Luminex multiplex technology,” Transfusion Medicine and Hemotherapy, vol. 36, no. 4, pp. 273–278, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. N. A. Hamed, A. F. Hano, H. A. Raouf, M. Gamal, and M. Eissa, “Relationship between HLA-DRB1*0101, DRB1*0301 alleles and interleukin-12 in haemophilic patients and hepatitis C virus positive hepatocellular carcinoma patients,” Egyptian Journal of Immunology, vol. 10, no. 1, pp. 17–26, 2003. View at Google Scholar · View at Scopus
  36. A. Piekarska, G. Woszczek, M. Sidorkiewicz, and J. Kuydowicz, “HLA class II alleles and response to hepatitis C treatment with interferon alpha2b,” Przeglad Epidemiologiczny, vol. 56, no. 1, pp. 123–128, 2002. View at Google Scholar · View at Scopus
  37. L. Alric, J. Izopet, M. Fort et al., “Study of the association between major histocompatibility complex class II genes and the response to interferon alpha in patients with chronic hepatitis C infection,” Human Immunology, vol. 60, no. 6, pp. 516–523, 1999. View at Publisher · View at Google Scholar · View at Scopus
  38. S. L. Rhodes, H. Erlich, K. A. Im et al., “Associations between the human MHC and sustained virologic response in the treatment of chronic hepatitis C virus infection,” Genes and Immunity, vol. 9, no. 4, pp. 328–333, 2008. View at Publisher · View at Google Scholar · View at Scopus
  39. R. L. Vitte, C. Fortier, J. P. Richardet et al., “HLA antigens in patients with chronic hepatitis C,” Tissue Antigens, vol. 45, no. 5, pp. 356–361, 1995. View at Google Scholar · View at Scopus
  40. S. Hüe, P. Cacoub, C. Renou et al., “Human leukocyte antigen class II alleles may contribute to the severity of hepatitis C virus-related liver disease,” Journal of Infectious Diseases, vol. 186, no. 1, pp. 106–109, 2002. View at Publisher · View at Google Scholar · View at Scopus
  41. C. Zavaglia, C. Bortolon, G. Ferrioli et al., “HLA typing in chronic type B, D and C hepatitis,” Journal of Hepatology, vol. 24, no. 6, pp. 658–665, 1996. View at Publisher · View at Google Scholar · View at Scopus
  42. M. Thursz, R. Yallop, R. Goldin, C. Trepo, and H. C. Thomas, “Influence of MHC class II genotype on outcome of infection with hepatitis C virus,” The Lancet, vol. 354, no. 9196, pp. 2119–2124, 1999. View at Google Scholar · View at Scopus
  43. J. Cursino-Santos, E. Donadi, A. Martinelli, P. Louzada-Junior, and N. Martinez-Rossi, “Evolution of hepatitis C virus infection under host factor influence in an ethnically complex population,” Liver International, vol. 27, pp. 1371–1378, 2007. View at Google Scholar
  44. D. Corghi, N. Gonçales, S. Marques, and J. Gonçales, “Distribution of the human leukocyte antigen class II alleles in Brazilian patients with chronic hepatitis C virus infection,” Brazilian Journal of Medical and Biological Research, vol. 41, pp. 884–889, 2008. View at Google Scholar
  45. P. A. Knolle, S. Kremp, T. Höhler, F. Krummenauer, P. Schirmacher, and G. Gerken, “Viral and host factors in the prediction of response to interferen-α therapy in chronic hepatitis C after long-term follow-up,” Journal of Viral Hepatitis, vol. 5, no. 6, pp. 399–406, 1998. View at Google Scholar · View at Scopus
  46. M. Romero-Gómez, M. F. González-Escribano, B. Torres et al., “HLA class I B44 is associated with sustained response to interferon + ribavirin therapy in patients with chronic hepatitis C,” American Journal of Gastroenterology, vol. 98, no. 7, pp. 1621–1626, 2003. View at Google Scholar · View at Scopus
  47. B. Kallinowski, S. Scherer, A. Mehrabi, L. Theilmann, and W. Stremmel, “Clinical impact of HLA DR B1 genotypes in chronic hepatitis C virus infection,” Transplantation Proceedings, vol. 31, no. 8, pp. 3346–3349, 1999. View at Google Scholar · View at Scopus
  48. S. Vejbaesya, S. Songsivilai, T. Tanwandee, S. Rachaibun, R. Chantangpol, and T. Dharakul, “HLA association with hepatitis C virus infection,” Human Immunology, vol. 61, no. 3, pp. 348–353, 2000. View at Publisher · View at Google Scholar · View at Scopus
  49. L. Alric, M. Fort, J. Izopet et al., “Genes of the major histocompatibility complex class II influence the outcome of hepatitis C virus infection,” Gastroenterology, vol. 113, no. 5, pp. 1675–1681, 1997. View at Publisher · View at Google Scholar · View at Scopus
  50. F. A. El-Chennawi, F. A. Auf, S. S. Metwally, Y. M. Mosaad, M. A. El-Wahab, and Z. E. Tawhid, “HLA-class II alleles in Egyptian patients with hepatocellular carcinoma,” Immunological Investigations, vol. 37, no. 7, pp. 661–674, 2008. View at Publisher · View at Google Scholar · View at Scopus
  51. M. Wawrzynowicz-Syczewska, J. A. Underhill, M. A. Clare, A. Boron-Kaczmarska, I. G. McFarlane, and P. T. Donaldson, “HLA class II genotypes associated with chronic hepatitis C virus infection and response to α-interferon treatment in Poland,” Liver, vol. 20, no. 3, pp. 234–239, 2000. View at Publisher · View at Google Scholar · View at Scopus
  52. S. K. Yoon, J. Y. Han, C. W. Pyo et al., “Association between human leukocytes antigen alleles and chronic hepatitis C virus infection in the Korean population,” Liver International, vol. 25, no. 6, pp. 1122–1127, 2005. View at Publisher · View at Google Scholar · View at Scopus