Human Leukocyte Antigen Class II Alleles (DQB1 and DRB1) as Predictors for Response to Interferon Therapy in HCV Genotype 4
Table 2
Frequencies and percentages of DQB1 alleles in HCV patients and healthy controls and in responders and nonresponders to combined treatment of interferon and ribavirin.
DQB1
HCV patients
Healthy controls
PC
Responders
Nonresponders
PC
()
()
*02
32 (51.6%)
41 (71.9%)
0.175
24 (63.2%)
6 (30%)
0.026#
*0201
31 (50.0%)
10 (17.5%)
0.015†
19 (50%)
10 (50%)
0.609
*0202
30 (48.4%)
10 (17.5%)
0.027†
18 (47.4%)
10 (50%)
1.000
*0204
30 (48.4%)
10 (17.5%)
0.027†
18 (47.4%)
10 (50%)
0.534
*0205
9 (14.5%)
35 (61.4%)
0.000†
7 (18.4%)
1 (5%)
0.241
*03
40 (64.5%)
53 (92.9%)
0.017†
27 (71.1%)
11 (55%)
0.255
*0301
27 (43.5%)
7 (12.3%)
0.022†
16 (42.1%)
9 (45%)
0.525
*0303
2 (3.2%)
35 (61.4%)
0.000†
1 (2.6%)
1 (5%)
0.575
*0309
27 (43.5%)
7 (12.3%)
0.022†
16 (42.1%)
9 (45%)
0.525
*0312
2 (3.2%)
35 (61.4%)
0.000†
1 (2.6%)
1 (5%)
0.575
*0313
7 (11.3%)
10 (17.5%)
0.695
2 (5.3%)
5 (25%)
0.041#
*0315
2 (3.2%)
35 (61.4%)
0.000†
1 (2.6%)
1 (5%)
0.575
*0319
27 (43.5%)
7 (12.3%)
0.022†
16 (42.1%)
9 (45%)
0.525
*0320
2 (3.2%)
35 (61.4%)
0.000†
1 (2.6%)
1 (5%)
0.575
*0321
4 (6.6%)
12 (21.1%)
0.224
3 (7.9%)
1 (5%)
1.000
*05
12 (19.4%)
10 (17.5%)
1.000
8 (21.1%)
3 (15%)
0.428
*0501
32 (51.6%)
41 (71.9%)
0.175
6 (15.8%)
2 (10%)
0.701
*0503
3 (4.8%)
19 (33.3%)
0.166
1 (2.6%)
2 (10%)
0.271
*06
20 (32.3%)
4 (7.0%)
0.030†
17 (44.7%)
2 (10%)
0.008#
*0601
5 (8.1%)
9 (15.8%)
0.823
3 (7.9%)
2 (10%)
0.568
*0602
2 (3.2%)
15 (26.3%)
0.170
2 (5.3%)
0 (0%)
0.425
*0603
10 (16.1%)
22 (38.6%)
0.171
8 (21.1%)
2 (10%)
0.468
*0627
3 (4.8%)
10 (17.5%)
0.325
1 (2.6%)
2 (10%)
0.271
*0628
10 (16.1%)
7 (12.3%)
0.886
8 (21.1%)
2 (10%)
0.250
*0633
2 (3.2%)
13 (22.8%)
0.173
2 (5.3%)
0 (0%)
0.540
*0634
2 (3.2%)
17 (29.8%)
0.085
1 (2.6%)
1 (5%)
0.575
Significant difference at PC ≤ 0.05 (corrected P after the Bonferroni correction) between responder and non-responder patients to treatment, †Significant difference at PC ≤ 0.05 (corrected P after Bonferroni correction) between patients and healthy group. Each patient may have multiple suballeles or none at all, so that totals are not always equal to “.”
