High Intestinal and Systemic Levels of Interleukin-23/T-Helper 17 Pathway in Chinese Patients with Inflammatory Bowel Disease

Table 3

Serum IL-12p40 and TL1A levels in patients with ulcerative disease (UC) according to disease characteristics.

Characteristics	UC; (𝑛=118)	IL-12p40 (pg/mL); Median (range)	TL1A (pg/mL); Median (range)
Gender
Male	54	275.12; (82.54–4756.60)	353.17; (178.15–5989.46)
Female	64	252.84; (68.16–4581.92)	355.85; (172.78–7113.23)
Age (years)
≤40	60	251.21; (68.16–4482.94)	339.75; (172.78–5425.89)
>40	58	256.91; (79.33–4756.60)	386.99; (182.45–7113.23)
Course of disease (years)
≤1.25	62	306.21; (79.33–4756.60)*	433.65; (172.78–7113.23)*
>1.25	56	214.40; (68.16–3355.24)	319.35; (176.00–5425.89)
Smoke habit
Yes	24	291.60; (82.54–4756.60)	385.38; (218.95–5989.46)
No	94	252.84; (68.16–4581.92)	353.17; (172.78–7113.23)
Family history
Yes	13	246.33; (79.33–1131.80)	318.81; (207.14–5425.89)
No	105	257.01; (68.16–4756.60)	358.54; (172.78–7113.23)
Extraintestinal manifestations
Yes	33	229.34; (79.33–3355.24)	310.22; (172.78–2198.54)*
No	85	258.43; (68.16–4756.60)	388.60; (176.00–7113.23)
Active disease	90	290.04; (68.16–4756.60)**	390.75; (172.78–7113.23)*
Inactive disease	28	185.60; (80.91–3193.59)	293.04; (176.00–2305.60)
Disease location
Extensive colitis	36	280.63; (82.54–4756.60)	347.26; (172.78–6831.63)
Distal colitis	82	252.84; (68.16–4581.92)	361.22; (176.00–7113.23)
Disease behavior
Initial onset	54	361.95; (79.33–4756.60)**	545.21; (207.14–7113.23)**
Chronic relapse/chronic continuous	64	214.39; (68.16–3355.24)	312.90; (172.78–5425.89)
Treatment
SASP/5-ASA monotherapy	66	239.69; (79.33–4581.92)	359.51; (176.00–6831.63)
Other drugs	52	268.61; (68.16–4756.60)	353.17; (172.78–7113.23)

^∗𝑃<0.05, ^∗∗𝑃<0.01.