Erythrocyte Shape Abnormalities, Membrane Oxidative Damage, and β-Actin Alterations: An Unrecognized Triad in Classical Autism

Table 3

Correlation matrix for elliptic erythrocyte shape, oxidative stress markers, and β-actin erythrocyte membrane content.

	Elliptocytes	4-HNE PAs	IE-NPBI	F2-IsoPs	𝛽-Actin content	4-HNE 𝛽-Actin; adducts
Elliptocytes		0.779; [0.630–0.873]; 𝑃<0.0001	0.334; [0.045–0.572]; 𝑃=0.00246	0.588; [0.356–0.752]; 𝑃<0.0001	−0.860; [−0.921 to −0.758]; 𝑃<0.0001	0.887; [0.803–0.937]; 𝑃<0.0001
4-HNE PAs			0.397; [0.117–0.618]; 𝑃=0.0068	0.774; [0.622–0.869]; 𝑃<0.0001	−0.886; [−0.936 to −0.801]; 𝑃<0.0001	0.889; [0.806–0.938]; 𝑃<0.0001
IE-NPBI				0.415; [0.139–0.632]; 𝑃=0.0045	−0.414; [−0.631 to –0.138]; 𝑃=0.0046	0.340; [0.052–0.576]; 𝑃=0.0223
F2-IsoPs					−0.628; [−0.778 to −0.410]; 𝑃<0.0001	0.579; [0.344–0.746]; 𝑃<0.0001
𝛽-Actin content						−0.960; [−0.978 to –0.929]; 𝑃<0.0001
4-HNE; 𝛽-Actin Adducts

Data are Spearman’s rho correlation coefficients (in square brackets are the 95% confidence intervals for regression).
IE-NPBI: intraerythrocyte nonprotein-bound-iron; F₂-IsoPs: F₂-isoprostanes; 4-HNE Pas: 4-HNE protein adducts.