Stimulation of MMP-1 and CCL2 by NAMPT in PDL Cells
Figure 1
Stimulation of gene expression and protein synthesis by NAMPT. Upregulation of genes by NAMPT (100 ng/mL) in PDL cells from 10 donors at 1 d (a). Upregulation of MMP-1 and CCL2 expression by NAMPT (100 ng/mL) in PDL cells from 10 donors at 3 d (b). Stimulation of MMP-1 expression by various concentrations of NAMPT in PDL cells from 3 donors at 1 d (c) and 3 d (d). Stimulation of CCL2 expression by various concentrations of NAMPT in PDL cells from 3 donors at 1 d (e) and 3 d (f). Stimulation of MMP-1 protein synthesis by NAMPT (100 ng/mL) in PDL cells from 6 donors at 1 d and 3 d (g). Stimulation of CCL2 protein synthesis by NAMPT (100 ng/mL) in PDL cells from 6 donors at 1 d and 3 d (h). All experiments were performed in triplicate and repeated at least twice. Mean ± SEM; *significantly () different from NAMPT-untreated cells (control).
