Stimulation of MMP-1 and CCL2 by NAMPT in PDL Cells
Figure 2
Intracellular pathways triggered by NAMPT. Stimulation of NFκB nuclear translocation by NAMPT at 60 min (a). Inhibition of the NAMPT-stimulated MMP-1 and CCL2 upregulation by preincubation of PDL cells with SP600125, a selective inhibitor of JNK, at 1 d (b). Images and data from one representative donor are shown. All experiments were performed in triplicate and repeated at least twice. Mean ± SEM; *significant () difference between groups.
