A Plasma Proteomic Approach in Rett Syndrome: Classical versus Preserved Speech Variant

Figure 1

In the pedigrees the two RTT sisters families are represented by grey circles (milder variant = preserved speech variant, PSV-RTT) or black circles (more severe phenotype = classical RTT) with their respective clinical scores as derived by the approbation of phenotypical severity scale [9]. In the 2-DE maps typical control plasma proteome (healthy control), RTT sisters Family 1 (no. 1, no. 2) and RTT sisters Family 2 (no. 3, no. 4) are shown. Arrows indicate the protein spots with significant variations in their major or minor relative volume; circles are used to indicate the absence of the spots (i.e., qualitative variations).