Ethyl Pyruvate Ameliorates Hepatic Ischemia-Reperfusion Injury by Inhibiting Intrinsic Pathway of Apoptosis and Autophagy
Figure 1
Effect of ethyl pyruvate on hepatic ischemia-reperfusion injury. The I/R and sham-operated mice were pretreated with ethyl pyruvate (20 mg/kg, 40 mg/kg, and 80 mg/kg) or saline. Mice were sacrificed 4 h, 8 h, and 16 h after reperfusion. The serum ALT and AST levels were assayed, shown in (a). Data represent means (SD) ( mice per time point per group). for saline VS saline + I/R, for saline + I/R VS I/R + EP (80 mg/kg). Representative hematoxylin and eosin (H&E) stained sections of liver are shown in (b). Original magnifications: ×200.
