Rheumatoid Arthritis Impacts on the Independent Relationships between Circulating Adiponectin Concentrations and Cardiovascular Metabolic Risk
Table 3
Impact of RA on the age and sex adjusted relationships between serum adipokine concentrations and metabolic risk factors and carotid atherosclerosis.
Leptin*
Adiponectin*
Potential characteristic
Interaction
RA ()
Non-RA ()
Interaction
RA ()
Non-RA ()
Partial
Partial
Partial
Partial
SBP
0.6
0.110
0.3
0.019
0.8
0.0009
0.257
0.005
0.093
0.4
DBP
0.0008
0.248
0.009
0.044
0.6
<0.0001
0.174
0.06
−0.009
0.9
MBP
0.09
0.201
0.04
0.034
0.7
<0.0001
0.229
0.01
0.037
0.8
Total C
0.0003
−0.022
0.8
0.123
0.1
0.2
−0.113
0.2
0.040
0.7
HDL C*
0.9
−0.117
0.2
−0.089
0.3
<0.0001
0.442
<0.0001
0.224
0.06
Total C-HDL C ratio
<0.0001
0.095
0.3
0.178
0.03
<0.0001
−0.466
<0.0001
−0.202
0.08
LDL C
<0.0001
−0.014
0.9
0.148
0.07
0.06
−0.187
0.049
−0.069
0.6
Non HDL C
0.002
0.048
0.6
0.159
0.05
0.0008
−0.322
0.0005
−0.021
0.9
Trig*
1.0
0.124
0.2
0.161
0.046
0.8
−0.366
<0.0001
−0.295
0.01
Trig-HDL C ratio*
0.9
0.139
0.2
0.163
0.045
0.0009
−0.456
<0.0001
−0.347
0.002
Glucose*
0.0003
0.084
0.4
0.082
0.3
0.1
−0.142
0.1
−0.152
0.2
cIMT
0.006
0.144
0.1
0.112
0.3
0.2
−0.076
0.4
−0.008
1.0
Additional adjustment was made for antihypertensive agent use, statins and oral glucose lowering agent, and insulin use in models that included blood pressure, lipid variables, and glucose concentrations, respectively. SBP: systolic blood pressure; DBP: diastolic blood pressure; C: cholesterol; HDL: high density lipoprotein; LDL: low density lipoprotein; trig: triglycerides; CRP: C-reactive protein; cIMT: carotid intima-media thickness.
*Logarithmically transformed in view of nonnormal distribution.
