Rheumatoid Arthritis Impacts on the Independent Relationships between Circulating Adiponectin Concentrations and Cardiovascular Metabolic Risk

Table 4

Impact of RA on the independent relationships of serum leptin and adiponectin concentrations with metabolic risk factors and carotid atherosclerosis.

	Leptin*				Adiponectin*
Potential characteristic	RA (𝑛=112)		Non-RA (𝑛=158)		RA (𝑛=119)		Non-RA (𝑛=77)
	Partial 𝑅	𝑃	Partial 𝑅	𝑃	Partial 𝑅	𝑃	Partial 𝑅	𝑃
SBP	−0.048	0.6	−0.018	0.9	0.331	0.0006	0.067	0.7
DBP	0.109	0.3	0.014	0.9	0.280	0.004	−0.050	0.8
MBP	0.042	0.7	−0.000	1.0	0.329	0.0007	0.001	1.0
Total C	−0.035	0.7	0.091	0.3	−0.115	0.3	−0.018	0.9
HDL C*	−0.113	0.3	0.009	0.9	0.335	0.0005	0.103	0.6
Total C-HDL C ratio	−0.076	0.5	0.068	0.5	−0.363	0.0002	−0.120	0.5
LDL C	−0.024	0.8	0.064	0.5	−0.149	0.1	−0.039	0.8
Non HDL C	0.038	0.7	0.087	0.4	−0.263	0.007	−0.036	0.8
Trig*	0.120	0.2	0.093	0.3	−0.271	0.005	−0.281	0.1
Trig-HDL C ratio*	0.136	0.2	0.066	0.5	−0.347	0.0003	−0.291	0.1
Glucose*	0.012	0.9	−0.020	0.8	−0.125	0.2	−0.151	0.4
cIMT	0.123	0.2	0.023	0.9	−0.096	0.3	0.008	1.0

Age, sex, body mass index (for leptin), waist (for adiponectin), C-reactive protein concentrations, angiotensin converting enzyme inhibitors and diuretic use, and stain therapy were adjusted for in each model. Additional adjustment was made for the use of any antihypertensive agents, oral glucose lowering agent and insulin use in models that included blood pressure and glucose concentrations, respectively. SBP: systolic blood pressure; DBP: diastolic blood pressure; C: cholesterol; HDL: high density lipoprotein; LDL: low density lipoprotein; trig: triglycerides; CRP: C-reactive protein; cIMT: carotid intima-media thickness.
*Logarithmically transformed in view of nonnormal distribution.