High Sugar Intake and Development of Skeletal Muscle Insulin Resistance and Inflammation in Mice: A Protective Role for PPAR-δ Agonism

Table 1

Effects of chronic in vivo treatment with GW0742 on mouse blood parameters after 30 weeks of dietary manipulation.

	Control; (𝑛 = 10)	Control + GW0742; (𝑛 = 6)	HFCS; (𝑛 = 10)	HFCS + GW0742; (𝑛 = 10)
IL-6 (pg/mL)	20.80 ± 2.11	18.90 ± 4.22	91.55 ± 16.47*	28.80 ± 7.99^§
Adiponectin (µg/mL)	4.53 ± 0.23	4.75 ± 0.46	1.93 ± 0.08*	3.69 ± 0.43^∗§
Leptin (pg/mL)	206.65 ± 18.77	198.07 ± 22.17	446.67 ± 52.61*	266.12 ± 41.21^∗§

HFCS: high-fructose corn syrup; IL-6: interleukin-6.
Data are means ± S.D.
^∗𝑃 < 0.01 versus Control.
^§𝑃 < 0.01 versus HFCS.