Marked Independent Relationship between Circulating Interleukin-6 Concentrations and Endothelial Activation in Rheumatoid Arthritis
Table 4
Independent associations between interleukin-6 concentrations and endothelial activation score in subgroups.
Subgroups
Partial
Population grouping
Black ()
0.416
<0.0001
White ()
0.378
0.0002
Age
≤55, y ()
0.366
0.002
>55, y ()
0.415
<0.0001
Sex
Women ()
0.382
<0.0001
Men ()
0.418
0.05
Smoking
Never ()
0.349
<0.0001
Ever ()
0.441
0.001
Missing data ()
BMI, kg/m2
≤29.9 ()
0.354
<0.0001
>29.9 ()
0.506
0.0005
Missing data ()
Hypertension
No ()
0.265
0.03
Yes ()
0.452
<0.0001
Chol-HDL chol ratio > 4
No ()
0.365
<0.0001
Yes ()
0.422
0.03
Missing data ()
RA duration, y
≤10 ()
0.327
0.003
>10 ()
0.437
<0.0001
Missing data ()
Rheumatoid factor
Negative ()
0.311
0.08
Positive ()
0.406
<0.0001
Missing data ()
DAS28
≤2.6 ()
0.268
0.05
>2.6 ()
0.443
<0.0001
Deformed joints
≤6 ()
0.335
0.002
>6 ()
0.439
<0.0001
Missing data ()
Age, sex, and cardiovascular risk factors were adjusted in each model as in Table 2. BMI: body mass index; HDL: high-density lipoprotein; RA: rheumatoid arthritis; DAS28: disease activity score in 28 joints (values of ≤2.6 and >2.6 indicate the presence of disease remission or mild disease activity and moderate or high disease activity, resp.).