Poly (ADP-Ribose) Polymerase Mediates Diabetes-Induced Retinal Neuropathy

<table>Diabetes-induced retinal PARP-1/2 activation were prevented by apocynin. PARP-1/2 expression in retina was quantified by Western blotting analysis using <i>β</i>-actin as a loading protein. Each measurement was made in duplicate or triplicate. The values are represented as mean ± SD of 5–7 rats in each of the three groups. N: normal, D: Diabetes, D + Apo: Diabetic rat received apocynin. <svg height="13.95" id="M18" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 66.324997 13.95" width="66.324997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared to normal and <svg height="15.775" id="M19" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 67.387497 15.775" width="67.387497" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared to diabetes.</table>

Mediators of Inflammation

fig8

Figure 8

Figure 8: Poly (ADP-Ribose) Polymerase Mediates Diabetes-Induced Retinal Neuropathy 