IRAK1/4-Targeted Anti-Inflammatory Action of Caffeic Acid
Figure 5
Effect of CA on inflammatory lesions in HCl/EtOH-treated stomachs in mice. (a) Mice orally administered either 200 mg/kg ((a) upper panel) or 100 mg/kg ((a) lower panel) or ranitidine (50 mg/kg) for 2 days were orally treated with HCl/EtOH. After 1 h, gastric lesions (the area (mm2)) in the stomach were measured with a pixel-counter; representative photos are shown. The gastritis index of the control group (inducer alone) was set to 100%. (b) Phosphoprotein or total protein levels of JNK, IRAK1, and IRAK4 in stomach lysates were determined by phosphospecific or total protein antibodies. Relative intensity was calculated using total levels by the DNR Bioimaging system. , compared to control.
