Helicobacter pylori Infection, Chronic Inflammation, and Genomic Transformations in Gastric MALT Lymphoma

Figure 1

Helicobacter pylori-caused gastritis is crucial in an evolution of gastric MALT lymphoma localized in the stomach. In the gastric mucosal cells, there are elevated levels of some cytokines, including proliferation-inducing ligand (APRIL), the protein with a crucial role in B-cell maturation and survival. APRIL induces also B-cells transformation and the lymphoma progression. Gastritis attracted macrophages, which, under a Helicobacter pylori infection, release large amounts of APRIL.