Peroxisome Proliferator-Activated Receptor Targets for the Treatment of Metabolic Diseases

Figure 1

Schematic representation of the functional domains of PPARs. The PPARs are composed of four different domains. The A/B domain is located in the N-terminal region with AF-1 which is responsible for phosphorylation, C domain is involved in DNA binding domain, the D domain is the region of cofactors coupling and E/F domain is the specific domain for the ligands, associated with E/F domain is AF-2, which promotes the recruitment of cofactors necessary for the process of gene transcription.