CD38 Ligation in Peripheral Blood Mononuclear Cells of Myeloma Patients Induces Release of Protumorigenic IL-6 and Impaired Secretion of IFNγ Cytokines and Proliferation

Table 1

Proliferation induced by CD38 ligation is specifically reduced in MM and MGUS patients.^a

Stimulus	MM; (𝑛=11)	MGUS; (𝑛=7)	Controls; (𝑛=15)
Anti-CD38	3.4±1.2; 𝑃=0.007	2.3±0.8; 𝑃=0.005	20.1±5.3
Anti-CD3	36.6±6.9	24.8±10	44.0±7.2
None	0.7±0.1	0.4±0.1	0.9±0.4

aPBMC from MM, MGUS patients, and healthy individuals were treated with indicated stimulus and ³H-Thymidine incorporation assayed. Results are expressed as mean ± SE of cpm (×10³). Number (𝑛) of individuals tested and statistical significance (Student’s 𝑡-test) of differences between MM or MGUS patients versus healthy controls are indicated.