CD38 Ligation in Peripheral Blood Mononuclear Cells of Myeloma Patients Induces Release of Protumorigenic IL-6 and Impaired Secretion of IFNγ Cytokines and Proliferation

Table 2

Altered response in IFN𝛾 and IL-6 cytokine release upon CD38 ligation in MM patients.^a

Stimulus	MM		Controls
	IFN𝛾 (10)	IL-6 (10)	IFN𝛾 (10)	IL-6 (10)
Anti-CD38	60±19	2929±878; 𝑃=0.041	295±156	820±162
Anti-CD3	1072±253	1638±677	10361±179	478±99
None	45±17	1088±482	4.2±1	236±103

aPBMC from MM patients and healthy individuals were treated with indicated stimulus and IFN𝛾 and IL-6 assayed by specific ELISA. Results are expressed as mean ± SE of pg/mL. Number (𝑛) of individuals tested and statistical significance (Student’s 𝑡-test) of differences between MM and healthy controls are indicated.