Dysregulated Circulating Dendritic Cell Function in Ulcerative Colitis Is Partially Restored by Probiotic Strain Lactobacillus casei Shirota
Figure 5
Intracellular cytokine production by stimulated T cells. (a) Summary graphs of all experiments representing proportions of T cells stimulated by 3% control and UC-DC producing TGFβ, IL-10, IFNγ, and IL-17 (). Paired -tests were applied; value <0.05 was considered statistically significant. (b) Histograms of TGFβ expression by dividing T cells, following stimulation by 3% control (no LcS) DC or control DC + 1 × 105/1 × 106 or 1 × 107 CFU/mL LcS. Example is from one experiment but representative of 3 independent experiments with similar results. Summary graphs of all experiments () representing the proportion of dividing T cells (stimulated by 3% DC in all cases) producing TGFβ. DC were from healthy controls (left graph) or UC patients (right graph). One-way ANOVA was applied; value <0.05 was considered statistically significant (*).
