The Possible Potential Therapeutic Targets for Drug Induced Gingival Overgrowth

Figure 1

Schematic diagram of interplay among profibrotic mediators. These proteins promote fibroblast activation and gingival fibrosis. Ang II: angiotensin II; CTGF: connective tissue growth factor; ET: endothelin; IGF: insulin-like growth factor; PDGF: platelet-derived growth factor; TGF: transforming growth factor; ECM: extracellular matrix.