SOCS3 Expression Correlates with Severity of Inflammation, Expression of Proinflammatory Cytokines, and Activation of STAT3 and p38 MAPK in LPS-Induced Inflammation <i>In Vivo</i>

<table>Western blot analysis of SOCS3, STAT3, and p38 MAPK protein expression in the LPS model of periodontal disease. Total protein was extracted from gingival tissue samples obtained from LPS and control sites at 7-, 15-, and 30-day periods. Activation of STAT3 and p38 as well as the expression of SOCS3 was determined. Increases in expression of SOCS3 and in the activation of STAT3 and p38 MAPK were observed at 7-, 15-, and 30-day experimental periods. Note that total STAT3 (including phosphorylated and nonphosphorylated forms) was also increased in the experimental group. The images are representative of the results obtained using samples from three different animals per period.</table>

Mediators of Inflammation

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Figure 3: SOCS3 Expression Correlates with Severity of Inflammation, Expression of Proinflammatory Cytokines, and Activation of STAT3 and p38 MAPK in LPS-Induced Inflammation <i>In Vivo</i> 

Figure 3 | SOCS3 Expression Correlates with Severity of Inflammation, Expression of Proinflammatory Cytokines, and Activation of STAT3 and p38 MAPK in LPS-Induced Inflammation In Vivo 