Minimally Modified LDL Upregulates Endothelin Type A Receptors in Rat Coronary Arterial Smooth Muscle Cells

Figure 1

Culturing with mmLDL enhanced the ET-1-induced contraction of rat coronary artery segments. (a) The concentration-dependent effect of culturing with mmLDL for 24 h; ^∗𝑃<0.05, ^∗∗𝑃<0.01versus organ culture for 24 h; ^##𝑃<0.01versus 5 μg/mL of mmLDL for 24 h. (b) The time-dependent effect of culturing with 10 μg/mL of mmLDL. ^▽𝑃<0.05, ^▽▽𝑃<0.01versus 10 μg/mL of mmLDL for 12 h. The data are presented as the mean ± SEM. 𝑛=8 coronary arteries, from that number of animals.

(a)

(b)