Local Overexpression of Interleukin-11 in the Central Nervous System Limits Demyelination and Enhances Remyelination
Figure 1
Scheme and effect of prophylactic overexpression of IL-11 on acute demyelination. (a) Murine IL-11-LV was administered stereotactically, 2 weeks prior to starting of the cuprizone (CUP) diet. PBS and eGFP-LV treatments were included as controls. After 5 weeks of cuprizone diet, animals were sacrificed and processed for immunohistochemistry. Panel (b) shows representative images of the midline corpus callosum in coronal brain sections of all groups, depicting demyelination (LFB), density of OPCs (NG2), OLs (CC1), and activated microglia (Mac-2/Iba-1). The images are chosen between the anterioposterior coordinates from −0.3 to −1.5 mm in reference to bregma. Scale bar: 200 μM.
