Hmgb1-IL-23-IL-17-IL-6-Stat3 Axis Promotes Tumor Growth in Murine Models of Melanoma
IL-17 promotes Stat3 activation. (a) Indicating p-Stat3 protein levels (analyzed by Western blot) in B16 tumor tissues from WT, WT + anti-γ δ TCR, and IL-17−/− groups (). (b) Tumor growth in B16 tumor-bearing wild-type mice injected by oral gavage with WP1066 at 40 mg/kg once per day (5 days on and 2 days off) (). (c) The number of PCNA+ cells in tumor tissues from B16-F10 tumor-bearing wild-type mice 2 weeks after inoculation (). (d) CD11b+Gr-1+ MDSCs in tumor samples of B16-F10 tumor-bearing wild-type mice (). (e) The number of blood vessels in tumor tissues from B16-F10 tumor-bearing wild-type mice (). The data show means ± SEM of tumor size and are representative of three independent experiments. .
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