Mediators of Inflammation / 2013 / Article / Tab 1

Review Article

The Role of Oxidized Low-Density Lipoproteins in Atherosclerosis: The Myths and the Facts

Table 1

Cohort studies demonstrating an association between oxidized low-density lipoprotein measurement and cardiovascular events.

Oxidative oxLDL testPopulation under studyCV endpointsNumber of eventsFollowup FindingsReference

OxLDL Abs 4E06326 menIMTna3 yearsOxLDL predicted IMT and carotid plaque progressionWallenfeldt et al. [88]

OxLDL Abs 4E06765 subjectsCV events77 CV events5 yearsOxLDL predicted CV eventsTsimikas et al. [90]

OxLDL Abs 4E06765 subjectsCV events82 CV events10 yearsOxLDL predicted CV eventsKiechl et al. [92]

OxPL/apoB, AutoAbs MDA-/Cu-oxLDL765 subjectsCV events138 CV events15 yearsOxPL/apoB predicted CV events and stroke; AutoAbs predicted CV events, stroke, and ACSTsimikas et al. [94]

MDA-LDL907 NIDDMCV events, MI152 CV events, 43 MI3.7 yearsMDA-LDL predicted MI and CV eventsLopes-Virella et al. [93]

AutoAbs Cu-oxLDL249 ESRDCV mortality74 CV deaths63 monthsAutoAbs predicted CV mortalityShoji et al. [84]

AutoAbs Cu-oxLDL94 ESRD on hemodialysisTotal mortality32 deaths24 monthsAutoAbs predicted mortalityBay s et al. [85]

AutoAbs Cu-oxLDL94 ESRD on hemodialysisCV mortality33 CV deaths4 yearsAutoAbs predicted CV mortalityBay s et al. [86]

OxLDL Abs DLH3246 pts with coronary angiographyCV events: cardiac death, MI, PTCA, and CABG76 CV events38 monthsOxLDL predicted CV eventsShimada et al. [87]

AutoAbs MDA-oxLDL734 IHD ptsCV mortality, MI, ACS, and CV events65 CV deaths, 153 CV events7.2 yearsOxLDL predicted CV death and eventsMaiolino et al. [81]

AutoAbs Cu-oxLDL 74 PTCA pts, 14 ctrRestenosis34 restenosis6 monthsAutoAbs predicted restenosis Lee et al. [107]

OxLDL Abs DLH3102 primary PTCA pts, 86 ctrRestenosis25 restenosis6 monthsOxLDL predicted restenosisNaruko et al. [89]

OxLDL Abs 4E06433 ACS ptsCV death, MI17 CV deaths, 57 MI2 yearsOxLDL predicted MIJohnston et al. [91]

OxLDL Abs FOH1a/DLH384 CHF pts (EF < 45%), 18 ctrCV death, CV hospitalization, and fatal arrhythmia26 CV events780 daysOxLDL predicted CV eventsTsutsui et al. [83]

Abs: antibodies; ACS: acute coronary syndrome; AutoAbs: autoantibodies; CABG: coronary artery by-pass surgery; CHF: congestive heart failure; Crt: controls; CV: cardiovascular; ESRD: end-stage renal disease; IHD: ischemic heart disease; IMT: intima-media thickness; MI: myocardial infarction; oxLDL: oxidized low-density lipoproteins; OxPL/apoB: oxidized phospholipids on apolipoprotein B-100; PTCA: percutaneous transluminal coronary angioplasty; pts: patients.

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