Cohort studies demonstrating an association between oxidized low-density lipoprotein measurement and cardiovascular events.
Oxidative oxLDL test Population under study CV endpoints Number of events Followup Findings Reference OxLDL Abs 4E06 326 men IMT na 3 years OxLDL predicted IMT and carotid plaque progression Wallenfeldt et al. [ 88] OxLDL Abs 4E06 765 subjects CV events 77 CV events 5 years OxLDL predicted CV events Tsimikas et al. [ 90] OxLDL Abs 4E06 765 subjects CV events 82 CV events 10 years OxLDL predicted CV events Kiechl et al. [ 92] OxPL/apoB, AutoAbs MDA-/Cu-oxLDL 765 subjects CV events 138 CV events 15 years OxPL/apoB predicted CV events and stroke; AutoAbs predicted CV events, stroke, and ACS Tsimikas et al. [ 94] MDA-LDL 907 NIDDM CV events, MI 152 CV events, 43 MI 3.7 years MDA-LDL predicted MI and CV events Lopes-Virella et al. [ 93] AutoAbs Cu-oxLDL 249 ESRD CV mortality 74 CV deaths 63 months AutoAbs predicted CV mortality Shoji et al. [ 84] AutoAbs Cu-oxLDL 94 ESRD on hemodialysis Total mortality 32 deaths 24 months AutoAbs predicted mortality Bay
s et al. [
85] AutoAbs Cu-oxLDL 94 ESRD on hemodialysis CV mortality 33 CV deaths 4 years AutoAbs predicted CV mortality Bay
s et al. [
86] OxLDL Abs DLH3 246 pts with coronary angiography CV events: cardiac death, MI, PTCA, and CABG 76 CV events 38 months OxLDL predicted CV events Shimada et al. [ 87] AutoAbs MDA-oxLDL 734 IHD pts CV mortality, MI, ACS, and CV events 65 CV deaths, 153 CV events 7.2 years OxLDL predicted CV death and events Maiolino et al. [ 81] AutoAbs Cu-oxLDL 74 PTCA pts, 14 ctr Restenosis 34 restenosis 6 months AutoAbs predicted restenosis
Lee et al. [ 107] OxLDL Abs DLH3 102 primary PTCA pts, 86 ctr Restenosis 25 restenosis 6 months OxLDL predicted restenosis Naruko et al. [ 89] OxLDL Abs 4E06 433 ACS pts CV death, MI 17 CV deaths, 57 MI 2 years OxLDL predicted MI Johnston et al. [ 91] OxLDL Abs FOH1a/DLH3 84 CHF pts (EF < 45%), 18 ctr CV death, CV hospitalization, and fatal arrhythmia 26 CV events 780 days OxLDL predicted CV events Tsutsui et al. [ 83]
Abs: antibodies; ACS: acute coronary syndrome; AutoAbs: autoantibodies; CABG: coronary artery by-pass surgery; CHF: congestive heart failure; Crt: controls; CV: cardiovascular; ESRD: end-stage renal disease; IHD: ischemic heart disease; IMT: intima-media thickness; MI: myocardial infarction; oxLDL: oxidized low-density lipoproteins; OxPL/apoB: oxidized phospholipids on apolipoprotein B-100; PTCA: percutaneous transluminal coronary angioplasty; pts: patients.