Review Article
The Role of Oxidized Low-Density Lipoproteins in Atherosclerosis: The Myths and the Facts
Table 2
Cohort studies demonstrating no association between oxidized low-density lipoprotein measurement and cardiovascular events.
| Oxidative oxLDL test | Population under study | CV endpoints | Number of events | Followup | Findings | Reference |
| OxLDL Abs 4E06 | 3033 elderly | CV events | 418 IHD, 120 MI | 3 years | OxLDL did not predict CV events at MV analysis | Holvoet et al. [95] |
| AutoAbs MDA-oxLDL | 2619 subjects | IHD (angina, ACS, and IHD death); CV events (IHD + TIA/stroke) | 151 IHD, 234 CV events | 8 years | AutoAbs did not predict CV events | Wilson et al. [99] |
| OxLDL Abs 4E06, AutoAbs MDA-/Cu-oxLDL | 919 subjects | Carotid atherosclerosis progression | na | 5 years | AutoAbs and oxLDL did not predict CV events | Mayr et al. [100] |
| AutoAbs Cu-oxLDL | 92 NIDDM, 80 ctr | CV events | 34 CV events, 15 CV deaths | 10 years | AutoAbs did not predict CV events | Uusitupa et al. [96] |
| OxLDL Abs 4E06 | 69 ESRD on hemodialysis, 33 ctr | CV events | 18 CV events | 43 months | OxLDL did not predict CV events | Lee et al. [101] |
| AutoAbs Cu-oxLDL | 415 IHD | CV events | 35 CV deaths/MI, 33 PTCA/CABG | 5 years | AutoAbs did not predict CV events | Erkkil et al. [97] |
| OxLDL Abs 4E06 | 687 PTCA pts | Restenosis, CV events | 135 restenosis, 181 CV events | 1 year | OxLDL did not predict CV events | Braun et al. [98] |
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Abs: antibodies; AutoAbs: autoantibodies; CABG: coronary artery by-pass surgery; CHF: congestive heart failure; Crt: controls; CV: cardiovascular; ESRD: end-stage renal disease; IHD: ischemic heart disease; IMT: intima-media thickness; MI: myocardial infarction; NIDDM: noninsulin dependent diabetes mellitus; oxLDL: oxidized low-density lipoproteins; PTCA: percutaneous transluminal coronary angioplasty; pts: patients.
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