Research Article

Effects of ω-3 Polyunsaturated Fatty Acids on Plasma Proteome in Rett Syndrome

Table 2

Biological functions for the identified proteins.

Proteins overexpressed in untreated RTT
Protein Biological function

Complement factor BImmune system and complement system regulation
Fibrinogen alpha chainCoagulation and signal transduction
Serum albuminTransport, regulation of colloidal osmotic pressure, and platelet activation
Alpha-1-antitrypsin (spot number 4)Acute phase response, coagulation, and proteases inhibition
Alpha-1-antitrypsin (spot number 5)Acute phase response, coagulation, and proteases inhibition
Serum albumin (C terminal fragment)Transport, regulation of colloidal osmotic pressure, and platelet activation
Haptoglobin (spot number 9)Acute phase response and hemoglobin binding
Transthyretin (spot number 11)Thyroid hormone binding and transport
Serum albumin (N terminal fragment)Transport, regulation of colloidal osmotic pressure, and platelet activation
Haptoglobin (spot number 15)Acute phase response and hemoglobin binding

Proteins underexpressed in untreated RTT
ProteinBiological function

Vitamin D-binding proteinVitamin D sterols carrier
Apolipoprotein A-IVLipid metabolism
ClusterinApoptosis, complement system regulation, and innate immunity
Apolipoprotein A-ILipid transport and metabolism
Retinol-binding protein 4Retinol transport and metabolism
Transthyretin (spot number 16)Thyroid hormone binding and transport