Association between Serum Interleukin-6 Concentration and Mortality in Patients with Coronary Artery Disease

Table 2

Hazard ratios of all-cause and cardiovascular mortality stratified by interleukine-6 tertiles and continuous levels.

Variable	Tertile 1	Tertile 2	Tertile 3	Per SD increment
Interleukine-6 (pg/mL)
Male	0.10–1.65	1.68–3.67	3.69–101.63
Female	0.09–1.63	1.68–3.38	3.39–43.19
No. of patients	238	241	239
No. of all-cause deaths	2	9	36
Person-years	545	595	523
Rate per 1000 person-years	3.7	15.1	68.8
Model 1*	[Reference]	4.80 (1.03–22.42), P = 0.046	19.44 (4.38–86.29), P < 0.001	3.05 (2.23–4.18), P < 0.001
Model 2^†	[Reference]	4.57 (0.95–21.93), P = 0.058	17.78 (3.93–77.65), P < 0.001	3.04 (2.22–4.17), P < 0.001
Model 3^‡	[Reference]	4.06 (0.88–18.78), P = 0.073	17.12 (3.11–71.76), P < 0.001	2.93 (2.11–4.08), P < 0.001
No. of CVD deaths	2	3	19
Person-years	545	595	523
Rate per 1000 person-years	3.7	5.0	36.3
Model 1*	[Reference]	1.32 (0.22–7.92), P = 0.760	10.69 (2.39–49.56), P < 0.001	2.74 (1.75–4.28), P < 0.001
Model 2^†	[Reference]	1.22 (0.19–7.79), P = 0.831	9.65 (2.01–47.88), P < 0.001	2.34 (1.56–4.07), P < 0.001
Model 3^‡	[Reference]	1.12 (0.16–7.77), P = 0.906	8.68 (1.88–37.51), P < 0.001	2.04 (1.34–3.68), P < 0.001

The quartiles are stratified by gender and the interleukin-6 levels are log transformed. The values are HR (95% confidence interval).
*Adjusted for age, sex, and body mass index. ^†Adjusted for the variables in model 1 plus smoking, alcohol use, hypertension, diabetes mellitus, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol. ^‡Adjusted for the variables in model 2 plus C-reactive protein (log transformed).