Association between Serum Interleukin-6 Concentration and Mortality in Patients with Coronary Artery Disease
Table 3
Hazard Ratios for All-cause and Cardiovascular Mortality According to Interleukine-6 Quartiles and Continuous Levels in Males.
Variable
Tertile 1
Tertile 2
Tertile 3
Per SD increment
Interleukine-6 (pg/mL)
0.01–1.65
1.68–3.67
3.69–101.63
No. of patients
147
150
148
No. of all-cause deaths
2
8
29
Person-years
340
362
304
Rate per 1000 person-years
5.9
22.1
95.4
Model 1*
[Reference]
4.54 (0.92–22.41),
16.34 (3.52–72.70), P < 0.001
3.18 (2.21–4.57), P < 0.001
Model 2†
[Reference]
4.19 (0.88–20.02),
13.89 (3.30–58.42), P < 0.001
3.16 (2.17–4.60), P < 0.001
Model 3‡
[Reference]
3.55 (0.75–16.75),
11.68 (3.04–37.56), P < 0.001
2.98 (2.12–4.18), P < 0.001
No. of CVD deaths
2
3
18
Person-years
340
362
304
Rate per 1000 person-years
5.9
8.3
59.2
Model 1*
[Reference]
1.32 (0.22–7.93),
11.35 (2.49–51.78), P = 0.002
3.41 (2.05–5.67), P < 0.001
Model 2†
[Reference]
1.14 (0.18–7.43),
10.81 (2.05–57.13), P = 0.005
3.34 (1.99–5.62), P < 0.001
Model 3‡
[Reference]
1.10 (0.16–7.74),
8.37 (1.93–36.22), P = 0.005
3.10 (1.98–4.85), P < 0.001
The interleukin-6 levels are log transformed. The values are HR (95% confidence interval). *Adjusted for age and body mass index. †Adjusted for the variables in model 1 plus smoking, alcohol use, hypertension, diabetes mellitus, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol. ‡Adjusted for the variables in model 2 plus C-reactive protein (log transformed).
