Clinical Study
Association of CFH and CFB Gene Polymorphisms with Retinopathy in Type 2 Diabetic Patients
Table 2
Genotype and allele frequencies of CFH and CFB polymorphisms in DR patients and DM controls.
| | SNP ID | Designation | Allele distribution (%) | value | Odds ratio | Genotype distribution (%) | value | Odds ratio | | DR ( = 554) | DM ( = 550) | () | (95% CI) | DR ( = 277) | DM ( = 275) | () | (95% CI) |
| | CFH | | rs800292 | G > A | A | 208 (37.5) | 250 (45.5) | 0.008 (0.04) | 0.72 (0.57–0.92) | AA | 38 (13.7) | 65 (23.6) | 0.15* | 0.77 (0.55–1.10) | | | Exon2 (I62V) | G | 346 (62.5) | 300 (54.4) | | | AG | 132 (47.7) | 120 (43.6) | 0.003† (0.015) | 0.51 (0.33–0.80) | | | | | | | | | GG | 107 (38.6) | 90 (32.7) | | |
| | CFB | | rs1048709 | G > A | A | 197 (35.6) | 154 (28.0) | 0.007 (0.035) | 1.42 (1.10–1.83) | AA | 40 (14.4) | 19 (6.9) | 0.07* | 1.36 (0.97–1.90) | | | Exon3 (R150R) | G | 357 (64.4) | 396 (72.0) | | | AG | 117 (42.2) | 116 (42.2) | 0.004† (0.02) | 2.27 (1.28–4.04) | | | | | | | | | GG | 120 (43.3) | 140 (50.9) | | | | rs537160 | G > A | A | 268 (48.4) | 266 (48.4) | 1.0 | 1.0 (0.79–1.27) | AA | 62 (22.4) | 60 (21.8) | 0.88* | 0.97 (0.66–1.43) | | | IVS7 | G | 286 (51.6) | 284 (51.6) | | | AG | 144 (52.0) | 146 (53.1) | 0.87† | 1.03 (0.69–1.55) | | | | | | | | | GG | 71 (25.6) | 69 (25.1) | | | | rs4151657 | T > C | C | 149 (26.9) | 138 (25.1) | 0.49 | 1.10 (0.84–1.44) | CC | 21 (7.6) | 14 (5.1) | 0.79* | 1.05 (0.75–1.46) | | | IVS10 | T | 405 (73.1) | 412 (74.9) | | | CT | 107 (38.6) | 110 (40.0) | 0.23† | 1.53 (0.76–3.07) | | | | | | | | | TT | 149 (53.8) | 151 (54.9) | | | | rs2072633 | A > G | G | 330 (59.6) | 311 (56.5) | 0.31 | 1.13 (0.89–1.44) | GG | 93 (33.6) | 86 (31.3) | 0.23* | 1.32 (0.84–2.07) | | | IVS17 | A | 224 (40.4) | 239 (43.5) | | | AG | 144 (52.0) | 139 (50.5) | 0.56† | 1.11 (0.78–1.59) | | | | | | | | | AA | 40 (14.4) | 50 (18.2) | | |
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Data analysis was performed by test.
*
value for dominant model.
† value for recessive model.
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