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Mediators of Inflammation
Volume 2013 (2013), Article ID 793505, 12 pages
http://dx.doi.org/10.1155/2013/793505
Review Article

The Involvement of Phospholipases A2 in Asthma and Chronic Obstructive Pulmonary Disease

Department of Immunopathology, Faculty of Biomedical Sciences and Postgraduate Training, Medical University of Lodz, 7/9 Zeligowskiego Street, Building 2, Room 122, 90-752 Lodz, Poland

Received 25 May 2012; Revised 2 January 2013; Accepted 27 February 2013

Academic Editor: Celeste C. Finnerty

Copyright © 2013 Ewa Pniewska and Rafal Pawliczak. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The increased morbidity, mortality, and ineffective treatment associated with the pathogenesis of chronic inflammatory diseases such as asthma and chronic obstructive pulmonary disease (COPD) have generated much research interest. The key role is played by phospholipases from the A2 superfamily: enzymes which are involved in inflammation through participation in pro- and anti-inflammatory mediators production and have an impact on many immunocompetent cells. The 30 members of the A2 superfamily are divided into 7 groups. Their role in asthma and COPD has been studied in vitro and in vivo (animal models, cell cultures, and patients). This paper contains complete and updated information about the involvement of particular enzymes in the etiology and course of asthma and COPD.