Differential Regulation of Inflammation and Immunity in Mild and Severe Experimental Asthma

Figure 3

Relative TLR and NLR mRNA expression in mouse whole lung tissue during mild and severe allergic asthma. The results are presented as mRNA expression levels relative to control mice. Data is shown as mean ± SEM. Statistical significance of differences was tested using Bonferroni’s post hoc test after one-way ANOVA. ^a𝑃<0.05 compared to control mice; ^b𝑃<0.05 compared to sensitized only mice; ^c𝑃<0.05 compared to challenged only mice; and ^e𝑃<0.05 compared to OVA-sensitized and challenged mice.

(a) Receptors involved in innate defence against bacteria

(b) Receptors involved in innate defence against viruses

(c) Receptors involved in innate defence against parasites

(d) Orphan receptors