Differential Regulation of Inflammation and Immunity in Mild and Severe Experimental Asthma
Table 2
Relative T-cell cytokine mRNA expression in mouse whole lung tissue during mild and severe allergic asthma.
Cytokine
Model
Control a
Sensitized only b
Challenged only c
Sensitized and challenged
Il2
Mild
1.00 ± 0.02
2.24 ± 1.41
12.96 ± 9.17
11.63 ± 11.32
Il2
Severe
1.00 ± 0.14
1.21 ± 0.20
1.53 ± 0.55
90.66 ± 37.70
Il4
Mild
1.00 ± 0.21
1.95 ± 0.49
12.29 ± 8.58
27.71 ± 27.25
Il4
Severe
1.00 ± 0.05
1.00 ± 0.11
0.82 ± 0.31
43.38 ± 38.41
Il5
Mild
1.00 ± 0.01
2.91 ± 2.08
8.09 ± 4.63
30.60 ± 0.00d
Il5
Severe
1.00 ± 0.22
0.62 ± 0.11
0.56 ± 0.02
8.02 ± 0.89a,b,c
Il6
Mild
1.00 ± 0.34
0.48 ± 0.09
2.94 ± 1.01
5.80 ± 3.49
Il6
Severe
1.00 ± 0.25
0.90 ± 0.46
1.45 ± 0.83
33.44 ± 4.31a,b,c
Il10
Mild
1.00 ± 0.28
2.22 ± 0.37
1.55 ± 0.49
18.93 ± 0.67a,b,c
Il10
Severe
1.00 ± 0.33
1.24 ± 0.14
0.89 ± 0.43
25.94 ± 8.76a,b,c
Il13
Mild
1.00 ± 0.32
2.75 ± 2.63
11.44 ± 7.40
9.58 ± 2.20
Il13
Severe
1.00 ± 0.28
0.98 ± 0.21
0.87 ± 0.37
64.21 ± 34.25
Tnfα
Mild
1.00 ± 0.11
1.01 ± 0.11
2.39 ± 0.87
4.83 ± 4.02
Tnfα
Severe
1.00 ± 0.29
0.86 ± 0.14
1.17 ± 0.25
8.78 ± 4.87
Ifnγ
Mild
1.00 ± 0.31
3.51 ± 2.77
25.26 ± 21.10
8.78 ± 1.16
Ifnγ
Severe
1.00 ± 0.00
0.75 ± 0.14
0.74 ± 0.26
82.32 ± 60.37
The values shown in the table are relative to the cytokine mRNA expression levels in control mice. Data is shown as mean ± SEM. Statistical significance of differences was tested using Bonferroni’s post hoc test after one-way ANOVA. compared to control mice; b compared to sensitized only mice; c compared to challenged only mice; da single value.
