Differential Regulation of Inflammation and Immunity in Mild and Severe Experimental Asthma

Table 4

Correlation between T-cell transcription factor mRNA expression and T-cell cytokine mRNA expression in whole lung tissue during mild and severe allergic asthma.

Transcription factor	Il2	Il4	Il5	Il6	Il10	Il13	Tnfα	Ifnγ
Tbet/mild	𝑟^2=0.60	𝑟^2=0.91	𝑟^2=0.93	𝑟^2=0.82	𝑃>0.05	𝑟^2=0.86	𝑟^2=0.88	𝑃>0.05
Tbet/severe	𝑟^2=0.92	𝑃>0.05	𝑃>0.05	𝑟^2=0.97	𝑟^2=0.96	𝑃>0.05	𝑃>0.05	𝑃>0.05
Gata3/mild	𝑃>0.05	𝑃>0.05	𝑃>0.05	𝑃>0.05	𝑃>0.05	𝑃>0.05	𝑃>0.05	𝑃>0.05
Gata3/severe	𝑃>0.05	𝑃>0.05	𝑃>0.05	𝑃>0.05	𝑃>0.05	𝑃>0.05	𝑃>0.05	𝑃>0.05
Rorγt/mild	𝑃>0.05	𝑃>0.05	𝑃>0.05	𝑃>0.05	𝑟^2=0.53	𝑃>0.05	𝑃>0.05	𝑃>0.05
Rorγt/severe	𝑟^2=0.50	𝑟^2=0.51	𝑟^2=0.42	𝑟^2=0.46	𝑟^2=0.54	𝑟^2=0.44	𝑃>0.05	𝑃>0.05
Foxp3/mild	𝑟^2=0.63	𝑟^2=0.52	𝑟^2=0.88	𝑟^2=0.58	𝑟^2=0.83	𝑃>0.05	𝑟^2=0.46	𝑃>0.05
Foxp3/severe	𝑟^2=0.98	𝑟^2=0.92	𝑟^2=0.98	𝑟^2=0.99	𝑟^2=0.58	𝑟^2=0.98	𝑃>0.05	𝑟^2=0.80

Correlation is calculated using linear regression analysis. 𝑅 square values are shown for the statistically significant correlations; 𝑃>0.05 represents nonsignificant correlations.