Prognostic Value of Inflammatory Mediators in 1-Year Outcome of Acute Ischemic Stroke with Middle Cerebral Artery Stenosis

Table 2

Patients’ characteristics by categorized MCA stenoocclusion.

	MCA stenoocclusion				𝑃 value
	0–49%; 𝑛=615	50%–69%; 𝑛=111	70%–99%; 𝑛=69	100%; 𝑛=182
Age, years^#	59.97 ± 11.04	62.44 ± 11.67	63.01 ± 11.60	57.33 ± 11.22	0.0001
Male	438 (71.22)	81 (72.97)	51 (73.91)	146 (80.22)	0.1202
Duration between symptom onset and blood tests^&, day	3 (1–5)	3 (1–5)	3 (1–5)	3 (1–5)	0.7268
Duration between symptom onset and MRI procedure^&, day	6 (4, 8)	6 (4, 9)	7 (5, 8)	7 (4, 9)	0.0767
Previous mRS score					0.1801
0	506 (82.28)	89 (80.18)	48 (69.57)	147 (80.77)
1	85 (13.82)	18 (16.22)	14 (20.29)	26 (14.29)
2	24 (3.90)	4 (3.60)	7 (10.14)	9 (4.95)
History of, yes (𝑛, %)
Previous cerebral ischemia, TIA, ICH, or SAH	152 (24.72)	29 (26.13)	28 (40.58)	57 (31.32)	0.0206
Hypertension	494 (80.33)	98 (88.29)	57 (82.61)	139 (76.37)	0.0899
Diabetes mellitus	253 (41.14)	58 (52.25)	34 (49.28)	64 (35.16)	0.0188
Hyperlipidemia	504 (81.95)	94 (84.68)	57 (82.61)	147 (80.77)	0.8626
Current smoking	308 (50.08)	50 (45.05)	24 (34.78)	102 (56.04)	0.0181
Heavy-to-severe drinking	136 (22.11)	28 (25.23)	15 (21.74)	41 (22.53)	0.9083
Ischemic heart disease	70 (11.38)	11 (9.91)	7 (10.14)	15 (8.24)	0.6731
NIHSS score on admission^&	4 (1, 7)	4 (1, 7)	3 (1, 8)	7 (2, 11)	<0.0001
NIHSS score at discharge^&	2 (0, 4)	2 (0, 4)	2 (1, 5)	4 (1, 8)	<0.0001
Peripheral level of inflammatory mediators
WBC^#, ×10^9/L	6.89 ± 1.90	6.80 ± 1.94	6.50 ± 1.75	7.20 ± 2.20	0.0583
HCY^#, μmol/L	17.52 ± 7.29	17.56 ± 6.58	17.21 ± 6.57	18.78 ± 8.31	0.2325
hs-CRP^&, mg/L	2.4 (0.9, 6.7)	2.75 (0.8, 9.5)	2.1 (0.7, 7.2)	3.8 (1.1, 0.2)	0.0580
Other laboratory findings on admission
Hgb^#, g/L	141.84 ± 18.21	141.24 ± 18.47	139.25 ± 14.08	144.10 ± 15.67	0.2094
PLT^#, ×10^9/L	214.67 ± 56.11	212.95 ± 60.36	202.15 ± 41.93	211.70 ± 57.98	0.3657
FBG^#, mmol/L	5.92 ± 2.27	6.21 ± 2.32	6.26 ± 2.16	5.78 ± 1.94	0.2566
Cr^#, μmol/L	78.27 ± 33.06	79.83 ± 22.80	76.84 ± 23.25	79.06 ± 21.62	0.9094
INR^#	0.98 ± 0.08	1.00 ± 0.35	0.97 ± 0.05	0.97 ± 0.05	0.3831
HDL^#, mmol/L	1.15 ± 0.28	1.11 ± 0.31	1.05 ± 0.23	1.08 ± 0.25	0.0038
LDL^#, mmol/L	2.76 ± 0.80	2.75 ± 0.83	2.77 ± 0.95	2.75 ± 0.92	0.9987
Recurrent stroke, yes	17 (2.76)	6 (5.41)	5 (7.25)	6 (3.30)	0.1649
one-year mRS
0–2	471 (79.16)	78 (70.27)	44 (63.77)	111 (62.71)	<0.0001
3–6	124 (20.84)	33 (29.73)	25 (36.23)	66 (37.29)

^#Continuous variables with normal distribution expressed as mean ± standard deviation.
^&Continuous variables with nonnormal distribution expressed as interquartile range (IQR).
Other values were expressed as 𝑛 (%).
SAH: subarachnoid hemorrhage; ICH: intracerebral hemorrhage; NIHSS: National Institute of Health Stroke Scale; WBC: white blood cell; Hgb: hemoglobin; PLT: platelet; FBG: free blood glycemia; Cr: creatinine; INR: international normalized ratio; HCY: homocysteine; hs-CRP: high sensitivity C-reactive protein; HDL: high-density lipoprotein; and LDL: low-density lipoprotein.