Pharmacogenetics of Chronic Pain and Its Treatment

Table 7

Impact of genetic variability in genes for transporters of neurotransmitters.

Transporter	Drug	Genetic variability	Effect	Reference
5-HTT	Remifentanil	Triallelic 5-HTTLPR	Better analgesic effect	[103]
	—	Low 5-HTT-expressing	Higher pain thresholds	[104, 105]
		Tandem-repeat polymorphism 2.10	Lesser temporomandibular joint pain and dysfunction	[106, 107]
		10/12 and 10/10 STin2.12 alleles	Protective effect against migraine	[108]
		14/14 sequence repeats	Higher frequency of abdominal pain	[109]
			More frequent in fibromyalgia patients	[110]
DAT	—	DAT*10	More frequent in migraine-without-aura-group	[111]
EAAT2	Analgesics	A allele in −181A/C	Higher usage	[112]