Review Article

Anti-Inflammatory Dimethylfumarate: A Potential New Therapy for Asthma?

Table 1

DMF effects on primary human lung cells.

FactorsDMF effectAfter stimulationCell typeReference

CXCL10 Inhibition at 10–100  M DMFTNF-α and/or IFN- and/or IL-1 ASMC[25, 27]
G-CSFNo effect  
Inhibition at 10  M DMF
IFN-   
TNF-α
ASMC[27]
EotaxinInhibition at 10–100  M DMFTNF-αASMC[26, 35]
RANTESInhibition at 10–100  M DMFTNF-αASMC[26, 35]
IL-8No effect at 0.01–1  M DMFRhinovirusLung fibroblasts[37]
GM-CSFInhibition at 100  M DMFTNF- and IL-1 prior to stimulation with human serum (10%)ASMC[38]
IL-6Inhibition at 10–100  M DMFTNF- or PDGF-BBASMC and lung fibroblasts[26, 28]
No effect at 0.01–1  M DMFRhinovirusLung fibroblasts[37]
Cell proliferationInhibition at 10–100  M DMFPDGF-BBASMC and lung fibroblasts[28, 36]