Review Article
Anti-Inflammatory Dimethylfumarate: A Potential New Therapy for Asthma?
Table 1
DMF effects on primary human lung cells.
| Factors | DMF effect | After stimulation | Cell type | Reference |
| CXCL10 | Inhibition at 10–100 M DMF | TNF-α and/or IFN- and/or IL-1 | ASMC | [25, 27] | G-CSF | No effect Inhibition at 10 M DMF | IFN- TNF-α | ASMC | [27] | Eotaxin | Inhibition at 10–100 M DMF | TNF-α | ASMC | [26, 35] | RANTES | Inhibition at 10–100 M DMF | TNF-α | ASMC | [26, 35] | IL-8 | No effect at 0.01–1 M DMF | Rhinovirus | Lung fibroblasts | [37] | GM-CSF | Inhibition at 100 M DMF | TNF- and IL-1 prior to stimulation with human serum (10%) | ASMC | [38] | IL-6 | Inhibition at 10–100 M DMF | TNF- or PDGF-BB | ASMC and lung fibroblasts | [26, 28] | No effect at 0.01–1 M DMF | Rhinovirus | Lung fibroblasts | [37] | Cell proliferation | Inhibition at 10–100 M DMF | PDGF-BB | ASMC and lung fibroblasts | [28, 36] |
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