Possible Involvement of TLRs and Hemichannels in Stress-Induced CNS Dysfunction via Mastocytes, and Glia Activation
Figure 1
Expression of toll-like receptors in microglia and their relationship with pannexin channels and P2X7 receptors. Microglia express TLRs 1 to 9, and in this figure only, TLRs 3 and 4 are shown responding to pathogen-associated molecular patterns of virus (TLR3) and Gram negative bacteria (TLR4). TLR3 is expressed in endosomal membranes (and also in cell surface) and recognizes nucleic acids of virus (dsRNA) and poly (I:C). We propose that microglia under activation with TLR ligands increase the expression of Panx1 channels and connexin HCs and the activity of P2X7 receptors.
